› 5tfk

X-ray diffraction
2.8Å resolution

Crystal Structure of Mouse Cadherin-23 EC19-21 WT

Released:
DOI: 10.2210/pdb5tfk/pdb
PDB entry 5tfk coloured by chain, front view.
PDB entry 5tfk coloured by chain, side view.
PDB entry 5tfk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M
Structure 26 1210-1225.e4 (2018)
PMID: 30033219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chain: A
Molecule details ›
Chain: A
Length: 350 amino acids
Theoretical weight: 38.21 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99PF4 (Residues: 1949-2289; Coverage: 10%)
Gene name: Cdh23
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 77.408Å b: 66.932Å c: 112.815Å
α: 90° β: 98.72° γ: 90°
R-values:
R R work R free
0.203 0.201 0.244
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.
Fettiplace et al. (2019)
1 more

2 mentions without citation

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh et al. (2018)
1 more