› 5tfl

X-ray diffraction
3.56Å resolution

Crystal Structure of Mouse Cadherin-23 EC7+8

Released:
DOI: 10.2210/pdb5tfl/pdb
PDB entry 5tfl coloured by chain, front view.
PDB entry 5tfl coloured by chain, side view.
PDB entry 5tfl coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M
Structure 26 1210-1225.e4 (2018)
PMID: 30033219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.53 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99PF4 (Residues: 666-886; Coverage: 7%)
Gene name: Cdh23
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P4132
Unit cell:
a: 185.809Å b: 185.809Å c: 185.809Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.221
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.
Fettiplace et al. (2019)
1 more

1 mention without citation

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh et al. (2018)