› 5tod

X-ray diffraction
2.96Å resolution

Transmembrane protein 24 SMP domain

Released:
DOI: 10.2210/pdb5tod/pdb
PDB entry 5tod coloured by chain, front view.
PDB entry 5tod coloured by chain, side view.
PDB entry 5tod coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.
Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM
Science 355 (2017)
PMID: 28209843

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-126995 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipid transfer protein C2CD2L Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 189 amino acids
Theoretical weight: 21.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14523 (Residues: 76-260; Coverage: 26%)
Gene names: C2CD2L, DLNB23, KIAA0285, TMEM24
Sequence domains: Synaptotagmin-like, mitochondrial and lipid-binding domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 24 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 83.395Å b: 117.098Å c: 148.133Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.239 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

39 review citations

The functional universe of membrane contact sites.
Prinz et al. (2020)
38 more

1 mention without citation

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.
Lees et al. (2017)