› 5txj

X-ray diffraction
1.13Å resolution

Polymorphic form 1 of amyloid-beta derived peptide - IFAEDV

Released:
DOI: 10.2210/pdb5txj/pdb
PDB entry 5txj coloured by chain, front view.
PDB entry 5txj coloured by chain, side view.
PDB entry 5txj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Distal amyloid β-protein fragments template amyloid assembly.
Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT
Protein Sci 27 1181-1190 (2018)
PMID: 29349888

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
amyloid-beta derived peptide Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 amino acids
Theoretical weight: 693 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 9.518Å b: 10.206Å c: 20.064Å
α: 96.22° β: 92.41° γ: 85.32°
R-values:
R R work R free
0.146 0.145 0.157
Expression system: Not provided

Quick links

Citations

1 review citation

Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta.
Wagner et al. (2022)
2 other articles

2 mentions without citation

Distal amyloid β-protein fragments template amyloid assembly.
Do et al. (2018)
1 more