› 5u3e

X-ray diffraction
2.3Å resolution

Crystal Structure of Native Lectin from Canavalia bonariensis Seeds (CaBo) complexed with alpha-methyl-D-mannoside

Released:
DOI: 10.2210/pdb5u3e/pdb
Model geometry
Fit model/data
PDB entry 5u3e coloured by chain, front view.
PDB entry 5u3e coloured by chain, side view.
PDB entry 5u3e coloured by chain, top view.
Source organism: Canavalia bonariensis
Primary publication:
Canavalia bonariensis lectin: Molecular bases of glycoconjugates interaction and antiglioma potential.
Cavada BS, Silva MTL, Osterne VJS, Pinto-Junior VR, Nascimento APM, Wolin IAV, Heinrich IA, Nobre CAS, Moreira CG, Lossio CF, Rocha CRC, Martins JL, Nascimento KS, Leal RB
Int J Biol Macromol 106 369-378 (2018)
PMID: 28803976

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157734 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lectin CaBo, 2nd part Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 25.55 KDa
Source organism: Canavalia bonariensis
UniProt:
  • Canonical: P58906 (Residues: 1-148; Coverage: 47%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand MMA 1 x MMA
Ligand MN 1 x MN
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: I222
Unit cell:
a: 64.169Å b: 70.03Å c: 111.649Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.283

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Citations

3 review citations

Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.
Barre et al. (2019)
2 more

2 mentions without citation

ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships.
Cavada et al. (2018)
1 more