› 5u4u

X-ray diffraction
1.9Å resolution

pseudoGTPase domain (pG1) of p190RhoGAP-A

Released:
DOI: 10.2210/pdb5u4u/pdb
PDB entry 5u4u coloured by chain, front view.
PDB entry 5u4u coloured by chain, side view.
PDB entry 5u4u coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
p190RhoGAP proteins contain pseudoGTPase domains.
Stiegler AL, Boggon TJ
Nat Commun 8 506 (2017)
PMID: 28894085

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103599 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho GTPase-activating protein 35 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.82 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A1L8F832 (Residues: 588-763; Coverage: 12%)
Gene names: arhgap35, arhgap35.L, grf-1, grlf1, p190-a, p190a, p190arhogap, p190rhogap

Ligands and Environments

2 bound ligands:
Ligand MLI 2 x MLI
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P6522
Unit cell:
a: 62.937Å b: 62.937Å c: 161.017Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.217
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer.
Weidle et al. (2019)
9 more

1 mention without citation

p190RhoGAP proteins contain pseudoGTPase domains.
Stiegler et al. (2017)