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› 5u5n

X-ray diffraction
2.1Å resolution

The dimeric crystal structure of HTPA Reductase from Sellaginella moellendorffii

Released:
DOI: 10.2210/pdb5u5n/pdb
Model geometry
Fit model/data
PDB entry 5u5n coloured by chain, front view.
PDB entry 5u5n coloured by chain, side view.
PDB entry 5u5n coloured by chain, top view.
Source organism: Selaginella moellendorffii
Primary publication:
Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly.
Watkin SAJ, Keown JR, Richards E, Goldstone DC, Devenish SRA, Grant Pearce F
Biochem J 475 137-150 (2018)
PMID: 29187521

Function and Biology Details

Reaction catalysed: 
(1) (S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112916 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-hydroxy-tetrahydrodipicolinate reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 279 amino acids
Theoretical weight: 30.29 KDa
Source organism: Selaginella moellendorffii
Expression system: Escherichia coli
UniProt:
  • Canonical: D8R6G2 (Residues: 10-288; Coverage: 97%)
Gene name: SELMODRAFT_168311
Sequence domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 57.358Å b: 61.746Å c: 151.408Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.278
Expression system: Escherichia coli

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Citations

2 citation in other articles

A dual-target herbicidal inhibitor of lysine biosynthesis.
Mackie et al. (2022)
1 more