› 5u6p

Electron Microscopy
3.51Å resolution

Structure of the human HCN1 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP

Released:
DOI: 10.2210/pdb5u6p/pdb
PDB entry 5u6p coloured by chain, front view.
PDB entry 5u6p coloured by chain, side view.
PDB entry 5u6p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the Human HCN1 Hyperpolarization-Activated Channel.
Lee CH, MacKinnon R
Cell 168 111-120.e11 (2017)
PMID: 28086084
Related structures: EMD-8512

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130084 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 660 amino acids
Theoretical weight: 74.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60741 (Residues: 1-890; Coverage: 74%)
Gene names: BCNG1, HCN1
Sequence domains:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 11 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 19 amino acids
Theoretical weight: 1.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand CMP 4 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.51Å
Relevant EMDB volumes: EMD-8512
Expression system: Homo sapiens

Quick links

Citations

45 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
44 more

25 mentions without citation

Structural insights into the mechanisms of CNBD channel function.
James et al. (2018)
24 more