› 5udc

X-ray diffraction
3.45Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230769 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
MEDI8897 Fab Heavy Chain Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 228 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
MEDI8897 Fab Light Chain Chains: C, G, L
Molecule details ›
Chains: C, G, L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fusion glycoprotein F0 Chains: A, D, F
Molecule details ›
Chains: A, D, F
Length: 568 amino acids
Theoretical weight: 63.22 KDa
Source organism: Human respiratory syncytial virus A2
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-513; Coverage: 89%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 103.78Å b: 126.31Å c: 162.31Å
α: 90° β: 102.56° γ: 90°
R-values:
R R work R free
0.178 0.175 0.232
Expression system: Homo sapiens

Quick links

Citations

44 review citations

Tackling COVID-19 with neutralizing monoclonal antibodies.
Corti et al. (2021)
43 more

2 mentions without citation

Antibody Epitopes of Pneumovirus Fusion Proteins.
Huang et al. (2019)
1 more