› 5udd

X-ray diffraction
4.3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231389 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fusion glycoprotein F0 Chains: A, B, C, D, E, F, G, H, I
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I
Length: 568 amino acids
Theoretical weight: 63.41 KDa
Source organism: Human Respiratory syncytial virus 9320
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6V2E7 (Residues: 1-513; Coverage: 89%)
Sequence domains: Fusion glycoprotein F0
MEDI8897 Fab Heavy Chain Chains: J, K, L, M, N, O
Molecule details ›
Chains: J, K, L, M, N, O
Length: 228 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
MEDI8897 Fab Light Chain Chains: P, Q, R, S, T, U
Molecule details ›
Chains: P, Q, R, S, T, U
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand SO4 15 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 229.02Å b: 229.02Å c: 343.25Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.239 0.236 0.294
Expression system: Homo sapiens

Quick links

Citations

44 review citations

Tackling COVID-19 with neutralizing monoclonal antibodies.
Corti et al. (2021)
43 more

2 mentions without citation

Antibody Epitopes of Pneumovirus Fusion Proteins.
Huang et al. (2019)
1 more