› 5ufl

X-ray diffraction
3Å resolution

Crystal structure of a CIP2A core domain

Released:
DOI: 10.2210/pdb5ufl/pdb
PDB entry 5ufl coloured by chain, front view.
PDB entry 5ufl coloured by chain, side view.
PDB entry 5ufl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
Wang J, Okkeri J, Pavic K, Wang Z, Kauko O, Halonen T, Sarek G, Ojala PM, Rao Z, Xu W, Westermarck J
EMBO Rep 18 437-450 (2017)
PMID: 28174209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186191 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein CIP2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 561 amino acids
Theoretical weight: 62.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TCG1 (Residues: 1-560; Coverage: 62%)
Gene names: CIP2A, KIAA1524
Sequence domains: CIP2A, N-terminal

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P65
Unit cell:
a: 153.276Å b: 153.276Å c: 105.44Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.257 0.256 0.281
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer.
Allen-Petersen et al. (2019)
12 more

2 mentions without citation

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
Wang et al. (2017)
1 more