› 5uiy

X-ray diffraction
1.69Å resolution

Structure of Bromodomain from human BAZ1A

Released:
DOI: 10.2210/pdb5uiy/pdb
PDB entry 5uiy coloured by chain, front view.
PDB entry 5uiy coloured by chain, side view.
PDB entry 5uiy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Non-canonical reader modules of BAZ1A promote recovery from DNA damage.
Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM, Bai T, Zhang J, Ciferri C, Cochran AG
Nat Commun 8 862 (2017)
PMID: 29021563

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192564 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 1A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 116 amino acids
Theoretical weight: 13.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NRL2 (Residues: 1425-1538; Coverage: 7%)
Gene names: ACF1, BAZ1A, HSPC317, WCRF180
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 41.432Å b: 44.92Å c: 72.077Å
α: 105.11° β: 89.95° γ: 102.92°
R-values:
R R work R free
0.198 0.196 0.235
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The emerging role of ISWI chromatin remodeling complexes in cancer.
Li et al. (2021)
1 more

1 mention without citation

Non-canonical reader modules of BAZ1A promote recovery from DNA damage.
Oppikofer et al. (2017)