› 5uja

Electron Microscopy
3.34Å resolution

Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4

Released:
DOI: 10.2210/pdb5uja/pdb
PDB entry 5uja coloured by chain, front view.
PDB entry 5uja coloured by chain, side view.
PDB entry 5uja coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.
Johnson ZL, Chen J
Cell 168 1075-1085.e9 (2017)
PMID: 28238471
Related structures: EMD-8560

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1460 amino acids
Theoretical weight: 159.7 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8HXQ5 (Residues: 205-1530; Coverage: 87%)
Gene names: ABCC1, MRP1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand LTX 1 x LTX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.34Å
Relevant EMDB volumes: EMD-8560
Expression system: Homo sapiens

Quick links

Citations

39 review citations

Revisiting the role of ABC transporters in multidrug-resistant cancer.
Robey et al. (2018)
38 more

29 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
28 more