› 5ujz

Electron Microscopy
4.8Å resolution

CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface - Class 1

Released:
DOI: 10.2210/pdb5ujz/pdb
PDB entry 5ujz coloured by chain, front view.
PDB entry 5ujz coloured by chain, side view.
PDB entry 5ujz coloured by chain, top view.
Source organisms:
Primary publication:
CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.
Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N
J Mol Biol 429 1829-1839 (2017)
PMID: 28506635
Related structures: EMD-8561

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207611 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 323 amino acids
Theoretical weight: 36.02 KDa
Source organism: Influenza A virus (A/Solomon Islands/3/2006(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A7UPX0 (Residues: 18-339; Coverage: 57%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 173 amino acids
Theoretical weight: 19.84 KDa
Source organism: Influenza A virus (A/Solomon Islands/3/2006(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A7UPX0 (Residues: 344-516; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin
scFv Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 266 amino acids
Theoretical weight: 27.63 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 18 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.8Å
Relevant EMDB volumes: EMD-8561
Expression systems:
  • Trichoplusia ni
  • Homo sapiens

Quick links

Citations

5 review citations

Hemagglutinin Structure and Activities.
Gamblin et al. (2021)
4 more

2 mentions without citation

CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.
Liu et al. (2017)
1 more