› 5uml

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3

Released:
DOI: 10.2210/pdb5uml/pdb
PDB entry 5uml coloured by chain, front view.
PDB entry 5uml coloured by chain, side view.
PDB entry 5uml coloured by chain, top view.
Source organisms:
Entry authors: Pazgier M, Gohain N, Tolbert WD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127322 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: A, B, E, G
Molecule details ›
Chains: A, B, E, G
Length: 85 amino acids
Theoretical weight: 9.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O15151 (Residues: 24-108; Coverage: 17%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain
PEPTIDE INHIBITOR M3 Chains: C, D, F, H
Molecule details ›
Chains: C, D, F, H
Length: 12 amino acids
Theoretical weight: 1.54 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 45.413Å b: 88.027Å c: 46.3Å
α: 90° β: 90.66° γ: 90°
R-values:
R R work R free
0.261 0.258 0.315
Expression system: Not provided

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