› 5up4

Electron Microscopy
9Å resolution

Structure of the HIV-1 Capsid Protein and spacer peptide 1 by Cryo-EM

Released:
DOI: 10.2210/pdb5up4/pdb
PDB entry 5up4 coloured by chain, front view.
PDB entry 5up4 coloured by chain, side view.
PDB entry 5up4 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Quenching protein dynamics interferes with HIV capsid maturation.
Wang M, Quinn CM, Perilla JR, Zhang H, Shirra R, Hou G, Byeon IJ, Suiter CL, Ablan S, Urano E, Nitz TJ, Aiken C, Freed EO, Zhang P, Schulten K, Gronenborn AM, Polenova T
Nat Commun 8 1779 (2017)
PMID: 29176596
Related structures: EMD-8582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gag protein Chains: B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S
Molecule details ›
Chains: B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S
Length: 221 amino acids
Theoretical weight: 24.65 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: B6DRA0 (Residues: 133-353; Coverage: 55%)
Gene name: gag
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9Å
Relevant EMDB volumes: EMD-8582
Expression system: Escherichia coli

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Citations

13 review citations

HIV-1 Maturation: Lessons Learned from Inhibitors.
Kleinpeter et al. (2020)
12 more

1 mention without citation

Quenching protein dynamics interferes with HIV capsid maturation.
Wang et al. (2017)