› 5upy

X-ray diffraction
2.35Å resolution

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Listeria Monocytogenes in the complex with IMP and Q21

Released:
DOI: 10.2210/pdb5upy/pdb
Model geometry
Fit model/data
PDB entry 5upy coloured by chain, front view.
PDB entry 5upy coloured by chain, side view.
PDB entry 5upy coloured by chain, top view.
Source organism: Listeria monocytogenes EGD-e
Entry authors: Kim Y, Makowska-Grzyska M, Osipiuk J, Anderson WF, Joachimiak A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187727 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 38.46 KDa
Source organism: Listeria monocytogenes EGD-e
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q926Y9 (Residues: 1-91, 221-488; Coverage: 74%)
Gene name: guaB
Sequence domains: IMP dehydrogenase / GMP reductase domain
Structure domains: Aldolase class I

Ligands and Environments

5 bound ligands:
Ligand IMP 1 x IMP
Ligand Q21 1 x Q21
Ligand CL 1 x CL
Ligand GOL 3 x GOL
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I432
Unit cell:
a: 174.165Å b: 174.165Å c: 174.165Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.164 0.208
Expression system: Escherichia coli BL21(DE3)

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