Function and Biology Details
Reaction catalysed:
2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] +NADP(+) + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Flavoprotein pyridine nucleotide cytochrome reductase
- Flavodoxin-like
- Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
- Flavodoxin/nitric oxide synthase
- Flavoprotein-like superfamily
- NADPH-cytochrome P450 reductase
- Oxidoreductase FAD/NAD(P)-binding
- NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
3 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
NADPH--cytochrome P450 reductase (preferred)
PDBe Complex ID:
PDB-CPX-132459 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADPH--cytochrome P450 reductase
Molecule details ›
Chains: A, B
Length: 622 amino acids
Theoretical weight: 70.71 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 622 amino acids
Theoretical weight: 70.71 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
P00388 (Residues: 57-678; Coverage: 92%)
Sequence domains:
Structure domains:
Ligands and Environments
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
RIGAKU MICROMAX-007
Spacegroup:
P212121
Expression system: Escherichia coli
