› 5ute

X-ray diffraction
2.05Å resolution

Kaposi's Sarcoma Herpesvirus Protease in Complex with Allosteric Inhibitor

Released:
DOI: 10.2210/pdb5ute/pdb
PDB entry 5ute coloured by chain, front view.
PDB entry 5ute coloured by chain, side view.
PDB entry 5ute coloured by chain, top view.
Source organism: Human gammaherpesvirus 8
Entry authors: Acker TM, Gable J, Bohn M-F, Craik CS

Function and Biology Details

Reaction catalysed: 
Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Assemblin Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 21.19 KDa
Source organism: Human gammaherpesvirus 8
Expression system: Escherichia coli
UniProt:
  • Canonical: O40922 (Residues: 23-215; Coverage: 35%)
Gene name: ORF17
Sequence domains: Assemblin (Peptidase family S21)
Structure domains: Herpesvirus/Caudovirus protease domain

Ligands and Environments

1 bound ligand:
Ligand 8M4 3 x 8M4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: I222
Unit cell:
a: 68.33Å b: 93.328Å c: 119.147Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.236
Expression system: Escherichia coli

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