We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 5utx

X-ray diffraction
2.46Å resolution

Crystal structure of thioredoxin-disulfide reductase from Vibrio vulnificus CMCP6 - apo form

Released:
DOI: 10.2210/pdb5utx/pdb
Model geometry
Fit model/data
PDB entry 5utx coloured by chain, front view.
PDB entry 5utx coloured by chain, side view.
PDB entry 5utx coloured by chain, top view.
Source organism: Vibrio vulnificus CMCP6
Primary publication:
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Inniss NL, Minasov G, Chang C, Tan K, Kim Y, Maltseva N, Stogios P, Filippova E, Michalska K, Osipiuk J, Jaroszewki L, Godzik A, Savchenko A, Joachimiak A, Anderson WF, Satchell KJF
Microbiol Resour Announc e0020025 (2025)
PMID: 40391899

Function and Biology Details

Reaction catalysed: 
[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181726 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase Chains: A, B
Molecule details ›
Chains: A, B
Length: 319 amino acids
Theoretical weight: 34.38 KDa
Source organism: Vibrio vulnificus CMCP6
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q7MLH2 (Residues: 3-321; Coverage: 99%)
Gene name: VV1455
Sequence domains: Pyridine nucleotide-disulphide oxidoreductase
Structure domains: FAD/NAD(P)-binding domain

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 120.031Å b: 120.031Å c: 79.185Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.254
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links