› 5v0v

X-ray diffraction
2.45Å resolution

Crystal structure of Equine Serum Albumin complex with etodolac

Released:
DOI: 10.2210/pdb5v0v/pdb
PDB entry 5v0v coloured by chain, front view.
PDB entry 5v0v coloured by chain, side view.
PDB entry 5v0v coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma.
Czub MP, Handing KB, Venkataramany BS, Cooper DR, Shabalin IG, Minor W
J Med Chem 63 6847-6862 (2020)
PMID: 32469516

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153012 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.77 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P35747 (Residues: 25-607; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

4 bound ligands:
Ligand TRS 4 x TRS
Ligand SO4 7 x SO4
Ligand 8QP 2 x 8QP
Ligand 8QS 2 x 8QS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P61
Unit cell:
a: 94.209Å b: 94.209Å c: 141.819Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.18 0.238

Quick links

Citations

4 review citations

Allergens and their associated small molecule ligands-their dual role in sensitization.
Chruszcz et al. (2021)
3 more

6 mentions without citation

Testosterone meets albumin - the molecular mechanism of sex hormone transport by serum albumins.
Czub et al. (2019)
5 more