› 5v2p

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171836 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Voltage-dependent L-type calcium channel subunit beta-2 Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 39.19 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VGC3 (Residues: 68-82, 83-189, 254-476; Coverage: 53%)
Gene names: Cacnb2, Cacnlb2
Sequence domains:
Structure domains:
Voltage-dependent L-type calcium channel subunit alpha-1C Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 2.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13936 (Residues: 427-445; Coverage: 1%)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1

Ligands and Environments

3 bound ligands:
Ligand NI 1 x NI
Ligand 1PE 2 x 1PE
Ligand 8VY 1 x 8VY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: R3
Unit cell:
a: 81.805Å b: 81.805Å c: 163.271Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.184 0.23
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Partners in Crime: Towards New Ways of Targeting Calcium Channels.
Noyer et al. (2019)
3 more

5 mentions without citation

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.
Ali et al. (2019)
4 more