› 5v40

X-ray diffraction
1.99Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125183 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polyketide synthase Pks13 Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 31.78 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: I6X8D2 (Residues: 1451-1733; Coverage: 16%)
Gene names: Rv3800c, pks13
Sequence domains: Thioesterase domain

Ligands and Environments

1 bound ligand:
Ligand JS1 2 x JS1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21212
Unit cell:
a: 88.017Å b: 109.364Å c: 57.029Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.217
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.
Ehrt et al. (2018)
14 more

2 mentions without citation

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Aggarwal et al. (2017)
1 more