› 5v5c

Electron crystallography
1.25Å resolution

VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2

Released:
DOI: 10.2210/pdb5v5c/pdb
PDB entry 5v5c coloured by chain, front view.
PDB entry 5v5c coloured by chain, side view.
PDB entry 5v5c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based inhibitors of tau aggregation.
Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS
Nat Chem 10 170-176 (2018)
PMID: 29359764
Related structures: EMD-8635

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 715 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 592-597; Coverage: 1%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.25Å
Relevant EMDB volumes: EMD-8635
Expression system: Not provided

Quick links

Citations

36 review citations

A new era for understanding amyloid structures and disease.
Iadanza et al. (2018)
35 more

7 mentions without citation

Electron Diffraction of 3D Molecular Crystals.
Saha et al. (2022)
6 more