5v8l

Electron Microscopy
4.3Å resolution

BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-212135 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (13 distinct):
Envelope glycoprotein gp160 Chains: A, C, D
Molecule details ›
Chains: A, C, D
Length: 481 amino acids
Theoretical weight: 54.06 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-505; Coverage: 55%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Transmembrane protein gp41 Chains: B, E, F
Molecule details ›
Chains: B, E, F
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
3BNC117 antibody, heavy chain Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 226 amino acids
Theoretical weight: 24.66 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PGT145 antibody, heavy chain Chain: J
Molecule details ›
Chain: J
Length: 267 amino acids
Theoretical weight: 28.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
3BNC117 antibody, light chain Chains: K, L, M
Molecule details ›
Chains: K, L, M
Length: 206 amino acids
Theoretical weight: 23.02 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
PGT145 antibody, light chain Chain: N
Molecule details ›
Chain: N
Length: 219 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.3Å
Relevant EMDB volumes: EMD-8643
Expression system: Homo sapiens