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› 5v8o

X-ray diffraction
3.1Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + ATP = 2',3'-cGAMP + 2 diphosphate.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185434 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic GMP-AMP synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 362 amino acids
Theoretical weight: 42.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N884 (Residues: 161-522; Coverage: 69%)
Gene names: C6orf150, CGAS, MB21D1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand 8ZM 3 x 8ZM
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 216.729Å b: 48.06Å c: 89.488Å
α: 90° β: 110.65° γ: 90°
R-values:
R R work R free
0.225 0.224 0.252
Expression system: Escherichia coli

Quick links

Citations

34 review citations

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.
Li et al. (2018)
33 more

3 mentions without citation

Host-pathogen protein-nucleic acid interactions: A comprehensive review.
Jain et al. (2022)
2 more