› 5va3

Electron Microscopy
4Å resolution

Cryo-EM structure of the human ether-a-go-go related K+ channel

Released:
DOI: 10.2210/pdb5va3/pdb
PDB entry 5va3 coloured by chain, front view.
PDB entry 5va3 coloured by chain, side view.
PDB entry 5va3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.
Wang W, MacKinnon R
Cell 169 422-430.e10 (2017)
PMID: 28431243
Related structures: EMD-8652

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171400 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily H member 2 Chain: A
Molecule details ›
Chain: A
Length: 795 amino acids
Theoretical weight: 88.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12809 (Residues: 1-1159; Coverage: 68%)
Gene names: ERG, ERG1, HERG, KCNH2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-8652
Expression system: Homo sapiens

Quick links

Citations

72 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
71 more

8 mentions without citation

An Update on the Structure of hERG.
Butler et al. (2019)
7 more