› 5vak

X-ray diffraction
1.7Å resolution

Crystal Structure of Beta-Klotho, Domain 1

Released:
DOI: 10.2210/pdb5vak/pdb
PDB entry 5vak coloured by chain, front view.
PDB entry 5vak coloured by chain, side view.
PDB entry 5vak coloured by chain, top view.
Source organisms:
Primary publication:
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J
Nature 553 501-505 (2018)
PMID: 29342135

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212553 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-klotho Chain: A
Molecule details ›
Chain: A
Length: 493 amino acids
Theoretical weight: 56.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q86Z14 (Residues: 30-522; Coverage: 47%)
Gene name: KLB
Sequence domains: Glycosyl hydrolase family 1
Nb914 Chain: B
Molecule details ›
Chain: B
Length: 134 amino acids
Theoretical weight: 14.84 KDa
Source organism: Lama glama
Expression system: Escherichia coli

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: C2
Unit cell:
a: 229.427Å b: 49.346Å c: 54.306Å
α: 90° β: 100.22° γ: 90°
R-values:
R R work R free
0.173 0.172 0.196
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

51 review citations

The Klotho proteins in health and disease.
Kuro-O M. (2019)
50 more

4 mentions without citation

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Lee et al. (2018)
3 more