› 5vb2

X-ray diffraction
3.2Å resolution

Crystal structure of the NavAb voltage-gated sodium channel in a closed conformation

Released:
DOI: 10.2210/pdb5vb2/pdb
PDB entry 5vb2 coloured by chain, front view.
PDB entry 5vb2 coloured by chain, side view.
PDB entry 5vb2 coloured by chain, top view.
Source organism: Aliarcobacter butzleri
Primary publication:
Structures of closed and open states of a voltage-gated sodium channel.
Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA
Proc Natl Acad Sci U S A 114 E3051-E3060 (2017)
PMID: 28348242

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 33.23 KDa
Source organism: Aliarcobacter butzleri
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains: Ion transport protein

Ligands and Environments

4 bound ligands:
Ligand CPS 8 x CPS
Ligand PX4 13 x PX4
Ligand PO4 4 x PO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Unit cell:
a: 125.963Å b: 129.853Å c: 196.128Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.233 0.266
Expression system: Trichoplusia ni

Quick links

Citations

17 review citations

Emerging Diversity in Lipid-Protein Interactions.
Corradi et al. (2019)
16 more

11 mentions without citation

P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models.
Tikhonov et al. (2022)
10 more