5vdh

X-ray diffraction
2.85Å resolution

Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin

Released:
Source organism: Homo sapiens
Primary publication:
Crystal Structures of Human GlyRα3 Bound to Ivermectin.
Structure 25 945-950.e2 (2017)
PMID: 28479061

Function and Biology Details

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
PDBe Complex ID:
PDB-CPX-130887 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine receptor subunit alpha-3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 362 amino acids
Theoretical weight: 41.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75311 (Residues: 34-342, 419-460; Coverage: 81%)
  • Best match: O75311-2 (Residues: 34-342, 404-445)
Gene name: GLRA3
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 119.065Å b: 119.065Å c: 429.934Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.226 0.236
Expression system: Spodoptera frugiperda