› 5vkg

Solution NMR

Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole

Released:
DOI: 10.2210/pdb5vkg/pdb
PDB entry 5vkg coloured by chain, ensemble of 20 models, front view.
PDB entry 5vkg coloured by chain, ensemble of 20 models, side view.
PDB entry 5vkg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Tsg101 chaperone function revealed by HIV-1 assembly inhibitors.
Strickland M, Ehrlich LS, Watanabe S, Khan M, Strub MP, Luan CH, Powell MD, Leis J, Tjandra N, Carter CA
Nat Commun 8 1391 (2017)
PMID: 29123089

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189274 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor susceptibility gene 101 protein Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99816 (Residues: 1-145; Coverage: 37%)
Gene name: TSG101
Sequence domains: UEV domain
Structure domains: Ubiquitin Conjugating Enzyme

Ligands and Environments

1 bound ligand:
Ligand 4N1 1 x 4N1
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

HIV-1 Tat: Role in Bystander Toxicity.
Ajasin et al. (2020)
10 more

3 mentions without citation

Recent Advances in HIV-1 Gag Inhibitor Design and Development.
Dick et al. (2020)
2 more