› 5vkq

Electron Microscopy
3.55Å resolution

Structure of a mechanotransduction ion channel Drosophila NOMPC in nanodisc

Released:
DOI: 10.2210/pdb5vkq/pdb
PDB entry 5vkq coloured by chain, front view.
PDB entry 5vkq coloured by chain, side view.
PDB entry 5vkq coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y
Nature 547 118-122 (2017)
PMID: 28658211
Related structures: EMD-8702

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1732 amino acids
Theoretical weight: 188.98 KDa
Source organism: Drosophila melanogaster
Expression system: Homo sapiens
UniProt:
  • Canonical: E0A9E1 (Residues: 1-1732; Coverage: 100%)
Gene names: CG11020, CG17468, CT30855, DmNompC, Dmel\CG11020, Dmel_CG11020, NOMPC, NompC, Nompc, ORE-13, TRPN, TRPN1, jf24, l(2)25Dc, l(2)jf24, nomp, nompC
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PCF 32 x PCF
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.55Å
Relevant EMDB volumes: EMD-8702
Expression system: Homo sapiens

Quick links

Citations

38 review citations

Discoveries in structure and physiology of mechanically activated ion channels.
Kefauver et al. (2020)
37 more

21 mentions without citation

Advances in TRP channel drug discovery: from target validation to clinical studies.
Koivisto et al. (2022)
20 more