› 5vna

X-ray diffraction
2.1Å resolution

Crystal structure of human YEATS domain

Released:
DOI: 10.2210/pdb5vna/pdb
PDB entry 5vna coloured by chain, front view.
PDB entry 5vna coloured by chain, side view.
PDB entry 5vna coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
Cho HJ, Li H, Linhares BM, Kim E, Ndoj J, Miao H, Grembecka J, Cierpicki T
ACS Chem Biol 13 2739-2746 (2018)
PMID: 30071723

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
YEATS domain-containing protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 148 amino acids
Theoretical weight: 17.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95619 (Residues: 1-148; Coverage: 65%)
Gene names: GAS41, YEATS4
Sequence domains: YEATS family

Ligands and Environments

3 bound ligands:
Ligand SO4 6 x SO4
Ligand EDO 6 x EDO
Ligand NHE 1 x NHE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 70.158Å b: 79.926Å c: 121.643Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

The histone variant H2A.Z in gene regulation.
Giaimo et al. (2019)
9 more

2 mentions without citation

GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
Cho et al. (2018)
1 more