› 5vre

X-ray diffraction
3.3Å resolution

Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from Chamaesiphon Minutus

Released:
DOI: 10.2210/pdb5vre/pdb
PDB entry 5vre coloured by chain, front view.
PDB entry 5vre coloured by chain, side view.
PDB entry 5vre coloured by chain, top view.
Source organism: Chamaesiphon minutus PCC 6605
Primary publication:
The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.
Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, Jiang Y
Nature 547 472-475 (2017)
PMID: 28723891

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel Cha6605_3372 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 203 amino acids
Theoretical weight: 22.69 KDa
Source organism: Chamaesiphon minutus PCC 6605
Expression system: Escherichia coli
UniProt:
  • Canonical: K9UJK2 (Residues: 1-203; Coverage: 100%)
Gene name: Cha6605_3372
Sequence domains: Endosomal/lysosomal potassium channel TMEM175

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 152.66Å b: 108.88Å c: 119.33Å
α: 90° β: 117.24° γ: 90°
R-values:
R R work R free
0.261 0.259 0.282
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Inflammation and immune dysfunction in Parkinson disease.
Tansey et al. (2022)
7 more

6 mentions without citation

Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease.
Tang et al. (2023)
5 more