Function and Biology Details
Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase S3, togavirin
- Flaviviral glycoprotein E, dimerisation domain
- Alphavirus E1 glycoprotein
- Alphavirus E2 glycoprotein
- Peptidase S1, PA clan, chymotrypsin-like fold
- Immunoglobulin E-set
- Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
- Flavivirus glycoprotein, central and dimerisation domain superfamily
5 more domains
Structure analysis Details
Assembly composition:
hetero 1440-mer (preferred)
Assembly name:
p130 and Capsid protein (preferred)
PDBe Complex ID:
PDB-CPX-102191 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
p130
Molecule details ›
Chains: A, B, C, D, M, N, O, P
Length: 866 amino acids
Theoretical weight: 95.54 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
Length: 866 amino acids
Theoretical weight: 95.54 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
- Canonical:
A0A0H4CWF2 (Residues: 326-1191; Coverage: 72%)
Assembly protein E3
Molecule details ›
Chains: U, V, W, X
Length: 60 amino acids
Theoretical weight: 6.93 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
Length: 60 amino acids
Theoretical weight: 6.93 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
- Canonical: Q5XXP3 (Residues: 266-324; Coverage: 5%)
Capsid protein
Molecule details ›
Chains: I, J, K, L
Length: 149 amino acids
Theoretical weight: 16.23 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
Length: 149 amino acids
Theoretical weight: 16.23 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
- Canonical: Q5XXP3 (Residues: 113-261; Coverage: 12%)
Spike glycoprotein E1
Molecule details ›
Chains: E, F, G, H
Length: 46 amino acids
Theoretical weight: 4.81 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
Length: 46 amino acids
Theoretical weight: 4.81 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
- Canonical: Q5XXP3 (Residues: 1203-1248; Coverage: 4%)
Spike glycoprotein E2
Molecule details ›
Chains: Q, R, S, T
Length: 81 amino acids
Theoretical weight: 8.82 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
Length: 81 amino acids
Theoretical weight: 8.82 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
- Canonical: Q5XXP3 (Residues: 668-748; Coverage: 7%)
