› 5vwl

Solution NMR

Solution NMR Structure of the Membrane Associated Segment of HIV-1 gp41 Cytoplasmic Tail

Released:
DOI: 10.2210/pdb5vwl/pdb
PDB entry 5vwl coloured by chain, ensemble of 20 models, front view.
PDB entry 5vwl coloured by chain, ensemble of 20 models, side view.
PDB entry 5vwl coloured by chain, ensemble of 20 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein.
Murphy RE, Samal AB, Vlach J, Saad JS
Structure 25 1708-1718.e5 (2017)
PMID: 29056482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180358 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 12.4 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6TAN6 (Residues: 750-854; Coverage: 12%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Recent Advances in HIV-1 Gag Inhibitor Design and Development.
Dick et al. (2020)
3 more

5 mentions without citation

Solution Structure and Membrane Interaction of the Cytoplasmic Tail of HIV-1 gp41 Protein.
Murphy et al. (2017)
4 more