› 5w2f

X-ray diffraction
1.4Å resolution

Crystal Structure of the C-terminal Domain of Human eIF2D at 1.4 A resolution

Released:
DOI: 10.2210/pdb5w2f/pdb
PDB entry 5w2f coloured by chain, front view.
PDB entry 5w2f coloured by chain, side view.
PDB entry 5w2f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.
Vaidya AT, Lomakin IB, Joseph NN, Dmitriev SE, Steitz TA
J Mol Biol 429 2765-2771 (2017)
PMID: 28736176

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2D Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41214 (Residues: 380-584; Coverage: 35%)
Gene names: EIF2D, HCA56, LGTN
Sequence domains: Translation initiation factor SUI1

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 50.65Å b: 50.65Å c: 183.653Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.14 0.172
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Translation Termination and Ribosome Recycling in Eukaryotes.
Hellen CUT. (2018)
1 more

2 mentions without citation

Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.
Vaidya et al. (2017)
1 more