› 5w3p

X-ray diffraction
1.92Å resolution

ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16

Released:
DOI: 10.2210/pdb5w3p/pdb
PDB entry 5w3p coloured by chain, front view.
PDB entry 5w3p coloured by chain, side view.
PDB entry 5w3p coloured by chain, top view.
Source organisms:
Primary publication:
A coiled conformation of amyloid-β recognized by antibody C706.
Teplyakov A, Obmolova G, Gilliland GL
Alzheimers Res Ther 9 66 (2017)
PMID: 28830506

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230796 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody C706 Fab LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antibody C706 Fab HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.37 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Amyloid-beta protein 40 Chain: P
Molecule details ›
Chain: P
Length: 18 amino acids
Theoretical weight: 1.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-687; Coverage: 2%)
Gene names: A4, AD1, APP

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 3 x GOL
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 65.2Å b: 69.88Å c: 104.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.236
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 citation in other articles

Solution-Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies.
Zhang et al. (2019)
1 more

1 mention without citation

A coiled conformation of amyloid-β recognized by antibody C706.
Teplyakov et al. (2017)