› 5w45

X-ray diffraction
2.49Å resolution

Function and Biology Details

Reaction catalysed: 
Cytosine in single-stranded DNA + H(2)O = uracil in single-stranded DNA + NH(3)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180068 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA dC->dU-editing enzyme APOBEC-3H Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 21.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6NTF7 (Residues: 2-177; Coverage: 88%)
Gene name: APOBEC3H
Sequence domains: APOBEC3

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 46.749Å b: 65.006Å c: 65.54Å
α: 90° β: 90.08° γ: 90°
R-values:
R R work R free
0.214 0.211 0.235
Expression system: Escherichia coli

Quick links

Citations

8 review citations

The Role of APOBECs in Viral Replication.
Xu et al. (2020)
7 more

7 mentions without citation

Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands.
Salter et al. (2018)
6 more