› 5we3

Solution NMR

Solution NMR structure of PaurTx-3

Released:
DOI: 10.2210/pdb5we3/pdb
PDB entry 5we3 coloured by chain, ensemble of 20 models, front view.
PDB entry 5we3 coloured by chain, ensemble of 20 models, side view.
PDB entry 5we3 coloured by chain, ensemble of 20 models, top view.
Source organism: Paraphysa scrofa
Primary publication:
Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins.
Agwa AJ, Huang YH, Craik DJ, Henriques ST, Schroeder CI
Toxins (Basel) 9 (2017)
PMID: 28805686

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160888 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-theraphotoxin-Ps1a Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 4.07 KDa
Source organism: Paraphysa scrofa
Expression system: Not provided
UniProt:
  • Canonical: P84510 (Residues: 1-34; Coverage: 100%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

1 review citation

Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways.
Dongol et al. (2019)
7 other articles

3 mentions without citation

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.
Agwa et al. (2018)
2 more