› 5wj8

X-ray diffraction
1.86Å resolution

Crystal Structure of Human Cadherin-23 EC13-14

Released:
DOI: 10.2210/pdb5wj8/pdb
PDB entry 5wj8 coloured by chain, front view.
PDB entry 5wj8 coloured by chain, side view.
PDB entry 5wj8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M
Structure 26 1210-1225.e4 (2018)
PMID: 30033219

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190534 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 24.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H251 (Residues: 1307-1523; Coverage: 7%)
Gene names: CDH23, KIAA1774, KIAA1812, UNQ1894/PRO4340
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand CL 1 x CL
Ligand K 1 x K
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6222
Unit cell:
a: 74.712Å b: 74.712Å c: 213.507Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.217 0.248
Expression system: Escherichia coli BL21

Quick links

Citations

2 review citations

Tonotopy in calcium homeostasis and vulnerability of cochlear hair cells.
Fettiplace et al. (2019)
1 more

1 mention without citation

Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Jaiganesh et al. (2018)