› 5wkv

X-ray diffraction
3.2Å resolution

Structure of an acid sensing ion channel in a resting state with calcium

Released:
DOI: 10.2210/pdb5wkv/pdb
PDB entry 5wkv coloured by chain, front view.
PDB entry 5wkv coloured by chain, side view.
PDB entry 5wkv coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Gating mechanisms of acid-sensing ion channels.
Yoder N, Yoshioka C, Gouaux E
Nature 555 397-401 (2018)
PMID: 29513651

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 439 amino acids
Theoretical weight: 50.24 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1XA76 (Residues: 25-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand CL 2 x CL
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 109.18Å b: 133.7Å c: 157.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.287 0.297
Expression system: Homo sapiens

Quick links

Citations

21 review citations

Unravelling the Interplay between Extracellular Acidosis and Immune Cells.
Erra Díaz et al. (2018)
20 more

11 mentions without citation

Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.
Rook et al. (2021)
10 more