› 5wky

X-ray diffraction
4Å resolution

Bromide sites in the structure of an acid sensing ion channel in a resting state

Released:
DOI: 10.2210/pdb5wky/pdb
PDB entry 5wky coloured by chain, front view.
PDB entry 5wky coloured by chain, side view.
PDB entry 5wky coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
Yoder N, Gouaux E
PLoS One 13 e0202134 (2018)
PMID: 30157194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 439 amino acids
Theoretical weight: 50.24 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1XA76 (Residues: 25-463; Coverage: 83%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 4 x NAG
Ligand CL 3 x CL
Ligand BA 1 x BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 109.55Å b: 134.49Å c: 159.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.282 0.281 0.299
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Cl- as a bona fide signaling ion.
Lüscher et al. (2020)
2 more

1 mention without citation

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
Yoder et al. (2018)