› 5wm9

X-ray diffraction
1.85Å resolution

Crystal Structure of TetR family regulator Rv0078 from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb5wm9/pdb
PDB entry 5wm9 coloured by chain, front view.
PDB entry 5wm9 coloured by chain, side view.
PDB entry 5wm9 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Cytokinin Signaling in Mycobacterium tuberculosis.
Samanovic MI, Hsu HC, Jones MB, Jones V, McNeil MR, Becker SH, Jordan AT, Strnad M, Xu C, Jackson M, Li H, Darwin KH
mBio 9 (2018)
PMID: 29921668

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129458 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 214 amino acids
Theoretical weight: 23.48 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O53623 (Residues: 1-201; Coverage: 100%)
Gene name: Rv0078
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 224.909Å b: 67.075Å c: 56.016Å
α: 90° β: 99.187° γ: 90°
R-values:
R R work R free
0.209 0.207 0.24
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Caseum: a Niche for Mycobacterium tuberculosis Drug-Tolerant Persisters.
Sarathy et al. (2020)
5 more