› 5woa

X-ray diffraction
3.9Å resolution

Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Gadolinium

Released:
DOI: 10.2210/pdb5woa/pdb
PDB entry 5woa coloured by chain, front view.
PDB entry 5woa coloured by chain, side view.
PDB entry 5woa coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Singh AK, Saotome K, Sobolevsky AI
Sci Rep 7 10669 (2017)
PMID: 28878326

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chain: A
Molecule details ›
Chain: A
Length: 672 amino acids
Theoretical weight: 77.13 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9R186 (Residues: 41-709; Coverage: 87%)
Gene name: Trpv6
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand GD 2 x GD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P4212
Unit cell:
a: 146.077Å b: 146.077Å c: 116.007Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.271 0.316
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy.
Madej et al. (2018)
9 more

4 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
3 more