› 5wor

X-ray diffraction
2.77Å resolution

Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R

Released:
DOI: 10.2210/pdb5wor/pdb
PDB entry 5wor coloured by chain, front view.
PDB entry 5wor coloured by chain, side view.
PDB entry 5wor coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS
Protein Sci 27 1231-1242 (2018)
PMID: 29453800

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132496 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 11 amino acids
Theoretical weight: 1.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00441 (Residues: 29-39; Coverage: 7%)
Gene name: SOD1

Ligands and Environments

2 bound ligands:
Ligand MLI 3 x MLI
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P3121
Unit cell:
a: 59.615Å b: 59.615Å c: 98.927Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.211 0.247
Expression system: Not provided

Quick links

Citations

3 review citations

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants.
Huai et al. (2019)
2 more

1 mention without citation

Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.
Sangwan et al. (2018)