› 5wp6

Electron Microscopy
3.8Å resolution

Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate

Released:
DOI: 10.2210/pdb5wp6/pdb
PDB entry 5wp6 coloured by chain, front view.
PDB entry 5wp6 coloured by chain, side view.
PDB entry 5wp6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Electron cryo-microscopy structure of a human TRPM4 channel.
Winkler PA, Huang Y, Sun W, Du J, Lü W
Nature 552 200-204 (2017)
PMID: 29211723
Related structures: EMD-8871

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1214 amino acids
Theoretical weight: 134.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TD43 (Residues: 1-1214; Coverage: 100%)
Gene names: LTRPC4, TRPM4
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand DVT 8 x DVT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-8871
Expression system: Homo sapiens

Quick links

Citations

37 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
36 more

11 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
10 more