› 5x0m

Electron Microscopy
3.8Å resolution

Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution

Released:
DOI: 10.2210/pdb5x0m/pdb
PDB entry 5x0m coloured by chain, front view.
PDB entry 5x0m coloured by chain, side view.
PDB entry 5x0m coloured by chain, top view.
Source organism: Periplaneta americana
Primary publication:
Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.
Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N
Science 355 (2017)
PMID: 28183995
Related structures: EMD-6698

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Sodium channel protein PaFPC1 Chain: A
Molecule details ›
Chain: A
Length: 1596 amino acids
Theoretical weight: 183.88 KDa
Source organism: Periplaneta americana
Expression system: Homo sapiens
UniProt:
  • Canonical: D0E0C2 (Residues: 1-1553; Coverage: 100%)
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-6698
Expression system: Homo sapiens

Quick links

Citations

46 review citations

Sodium channels and pain: from toxins to therapies.
Cardoso et al. (2018)
45 more

33 mentions without citation

Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.
Nathan et al. (2021)
32 more