› 5x4f

Solution NMR

Solution Structure of the N-terminal Domain of TDP-43

Released:
DOI: 10.2210/pdb5x4f/pdb
PDB entry 5x4f coloured by chain, ensemble of 10 models, front view.
PDB entry 5x4f coloured by chain, ensemble of 10 models, side view.
PDB entry 5x4f coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The N-terminal dimerization is required for TDP-43 splicing activity.
Jiang LL, Xue W, Hong JY, Zhang JT, Li MJ, Yu SN, He JH, Hu HY
Sci Rep 7 6196 (2017)
PMID: 28733604

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171557 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13148 (Residues: 1-77; Coverage: 19%)
Gene names: TARDBP, TDP43
Sequence domains: TAR DNA-binding protein 43, N-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.
Prasad et al. (2019)
14 more

4 mentions without citation

Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases.
Loch et al. (2023)
3 more