› 5x8s

X-ray diffraction
2.2Å resolution

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid.

Released:
DOI: 10.2210/pdb5x8s/pdb
PDB entry 5x8s coloured by chain, front view.
PDB entry 5x8s coloured by chain, side view.
PDB entry 5x8s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.
Noguchi M, Nomura A, Murase K, Doi S, Yamaguchi K, Hirata K, Shiozaki M, Hirashima S, Kotoku M, Yamaguchi T, Katsuda Y, Steensma R, Li X, Tao H, Tse B, Fenn M, Babine R, Bradley E, Crowe P, Thacher S, Adachi T, Kamada M
Genes Cells 22 535-551 (2017)
PMID: 28493531

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124207 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAR related orphan receptor C Chains: A, B
Molecule details ›
Chains: A, B
Length: 258 amino acids
Theoretical weight: 29.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: G1RH57 (Residues: 240-497; Coverage: 52%)
Gene name: RORC
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 6Q5 2 x 6Q5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P61
Unit cell:
a: 116.95Å b: 116.95Å c: 77.96Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.176 0.235
Expression system: Escherichia coli

Quick links

Citations

1 review citation

RORγ Structural Plasticity and Druggability.
Huang et al. (2020)
4 other articles

2 mentions without citation

Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction.
Noguchi et al. (2018)
1 more